GPP 78
GPP78
CAS: 1202580-59-3
Molecular Formula: C27H29N5O
GPP 78 - Names and Identifiers
| Name | GPP78 |
| Synonyms | GPP78 GPP 78 CAY10618 CAY10618 Exclusive N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide 1H-1,2,3-Triazole-1-octanaMide, N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)- |
| CAS | 1202580-59-3 |
GPP 78 - Physico-chemical Properties
| Molecular Formula | C27H29N5O |
| Molar Mass | 439.55 |
| Density | 1.15±0.1 g/cm3(Predicted) |
| pKa | 14.80±0.70(Predicted) |
| Storage Condition | -20°C |
GPP 78 - Reference Information
| biological activity | GPP78 (Cayman 10618) is a potent inhibitor of nicotinamide phosphoribosyl transferase (Nampt), the IC50 for NAD depletion was 3 nM. GPP78 is toxic to neuroblastoma cells SH-SY5Y by inducing autophagy with an IC50 of 3.8 nM. GPP78 has anti-cancer and anti-inflammatory effects. |
| Target | Nampt; Autophagy |
| Cell Line: | SH-SY5Y cells |
| Concentration: | 10 nM |
| Incubation Time: | 24 hours, 40 hours |
| Result: | Punctate staining of LC3-II and the formation of autophagolysosomes were observable. Significantly reduced the demyelination associated with SCI. And significantly ameliorated the functional deficits induced by SCI. |
| Animal Model: | Male adult CD1 mice (25-30 g) with spinal cord injury (SCI) |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days |
Last Update：2024-04-10 22:29:15
